Endogenous antimicrobial peptides and skin infections in atopic dermatitis.

  title={Endogenous antimicrobial peptides and skin infections in atopic dermatitis.},
  author={Peck Y. Ong and Takaaki Ohtake and Corinne Brandt and Ian Strickland and Mark Boguniewicz and Tomas Ganz and Richard L Gallo and Donald Y. M. Leung},
  journal={The New England journal of medicine},
  volume={347 15},
BACKGROUND The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and beta-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis. METHODS The expression of LL-37 and HBD-2 protein in skin-biopsy… CONTINUE READING
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