Endogenous antigen tunes the responsiveness of naive B cells but not T cells

  title={Endogenous antigen tunes the responsiveness of naive B cells but not T cells},
  author={Julie Zikherman and Ramya Parameswaran and Arthur Weiss},
In humans, up to 75% of newly generated B cells and about 30% of mature B cells show some degree of autoreactivity. Yet, how B cells establish and maintain tolerance in the face of autoantigen exposure during and after development is not certain. Studies of model B-cell antigen receptor (BCR) transgenic systems have highlighted the critical role of functional unresponsiveness or ‘anergy’. Unlike T cells, evidence suggests that receptor editing and anergy, rather than deletion, account for much… CONTINUE READING
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