Endogenous and exogenous polyamines in support of tumor growth.

  title={Endogenous and exogenous polyamines in support of tumor growth.},
  author={Nikolaus Seiler and Shakir Sarhan and C{\'e}dric Grauffel and Rosemary E. Jones and Bernd Knoedgen and J. P. Moulinoux},
  journal={Cancer research},
  volume={50 16},
The combination of inhibitors of ornithine decarboxylase and polyamine oxidase and of antibiotics suitable for the (partial) decontamination of the gastrointestinal tract with a polyamine-deficient diet reduced the growth rate of Lewis lung carcinoma by more than 80%. The formation of lung metastases was prevented by 70 to 100%, depending on the treatment. The reduction of tumor growth was accompanied by a decrease of tissue polyamine concentrations, a reduced rate of tumor cell proliferation… CONTINUE READING
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