Endogenous and exogenous pathways maintain the reductive capacity of the phagosome.

@article{Balce2016EndogenousAE,
  title={Endogenous and exogenous pathways maintain the reductive capacity of the phagosome.},
  author={Dale R Balce and Catherine J. Greene and Pankaj Tailor and Robin M Yates},
  journal={Journal of leukocyte biology},
  year={2016},
  volume={100 1},
  pages={17-26}
}
Although endosomes, lysosomes, and phagosomes require a reductive environment for the optimal activity of disulfide reductases and other thiol-dependent enzymes, how these reductive environments are established and maintained remain unknown. Our goal in this study was to begin to elucidate the redox control systems responsible for maintaining redox-sensitive enzymatic activities in the phagolysosome of murine macrophages. Through the use of specific inhibitors and genetic knockdown of known… CONTINUE READING