Endogenous and exogenous forms of the same antigen are processed from different pools to bind MHC class II molecules in endocytic compartments.

@article{Bonifaz1999EndogenousAE,
  title={Endogenous and exogenous forms of the same antigen are processed from different pools to bind MHC class II molecules in endocytic compartments.},
  author={Laura C. Bonifaz and Silvia Arzate and Jos{\'e} Francisco Herrera Moreno},
  journal={European journal of immunology},
  year={1999},
  volume={29 1},
  pages={119-31}
}
The current studies were carried out to examine the basis for the differences in the antigenic peptides generated from exogenous and endogenous forms of hen egg white lysozyme (HEL). The role of different intracellular compartments in the generation and binding of HEL peptides derived from two endogenous forms of HEL, either secreted (sHEL) or retained in the endoplasmic reticulum (ER, KDELHEL), presented by MHC class II molecules was examined and compared to exogenous HEL. Initially it was… CONTINUE READING

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