Endogenous alkaloids in man--synthesis, analytics, in vivo identification, and medicinal importance.

Abstract

The in vitro and in vivo condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B6, chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.

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@article{Bringmann1991EndogenousAI, title={Endogenous alkaloids in man--synthesis, analytics, in vivo identification, and medicinal importance.}, author={Gerhard Bringmann and Doris Feineis and Heather Friedrich and Annegret Hille}, journal={Planta medica}, year={1991}, volume={57 7}, pages={S73-84} }