Endogenous adenosine modulates alpha 2- but not alpha 1-adrenergic constriction of coronary arterioles.

Abstract

In the coronary circulation alpha-adrenergic constriction competes with metabolic vasodilation. Because adenosine is produced by the working myocardium and metabolic stimulation results in arteriolar dilation, we tested the hypothesis that coronary arteriolar alpha-adrenergic constriction is attenuated by the endogenous production of adenosine. To test this… (More)

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