Endogenous active efflux of norfloxacin in susceptible Escherichia coli.

@article{Cohen1988EndogenousAE,
  title={Endogenous active efflux of norfloxacin in susceptible Escherichia coli.},
  author={Seth P. Cohen and David C. Hooper and Jon G See Wolfson and K. De Souza and Laura M. McMurry and Stuart B. Levy},
  journal={Antimicrobial agents and chemotherapy},
  year={1988},
  volume={32 8},
  pages={1187-91}
}
Escherichia coli was shown to have an energy-dependent reduced uptake of the fluoroquinolone antimicrobial agent norfloxacin. Studies of everted inner membrane vesicles suggested that this reduced accumulation involved a carrier-mediated norfloxacin active efflux generated by proton motive force with an apparent Km of 0.2 mM and a Vmax of 3 nmol min-1 mg of protein-1. Other hydrophilic, but not hydrophobic, quinolones competed with norfloxacin for transport. Porin (OmpF)-deficient E. coli cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Heavy metal-induced glutathione accumulation and its role in heavy metal detoxification in Phanerochaete chrysosporium

Piao Xu, Liang Liu, +10 authors Yibin He
Applied Microbiology and Biotechnology • 2014
View 3 Excerpts
Highly Influenced

The newer fluoroquinolones.

Infectious disease clinics of North America • 2009

Accumulation of norfloxacin by Bacteroides fragilis.

Antimicrobial agents and chemotherapy • 2000
View 1 Excerpt

Similar Papers

Loading similar papers…