Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Abstract

The use of neural progenitor cells (NPCs) is limited by the incomplete knowledge of the extracellular signals regulating their proliferation and survival. We report that cultured mouse NPCs express functional mGlu3 and mGlu5 metabotropic glutamate receptors. Pharmacological blockade of both receptors reduced NPC proliferation and survival, whereas… (More)
DOI: 10.1038/sj.cdd.4401639

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