Endogenous activation of adenosine A1 receptors, but not P2X receptors, during high-frequency synaptic transmission at the calyx of Held.

@article{Wong2006EndogenousAO,
  title={Endogenous activation of adenosine A1 receptors, but not P2X receptors, during high-frequency synaptic transmission at the calyx of Held.},
  author={Adrian Y. C. Wong and Brian Billups and Jamie Johnston and Richard J. Evans and Ian D. Forsythe},
  journal={Journal of neurophysiology},
  year={2006},
  volume={95 6},
  pages={3336-42}
}
Activation of presynaptic receptors plays an important role in modulation of transmission at many synapses, particularly during high-frequency trains of stimulation. Adenosine-triphosphate (ATP) is coreleased with several neurotransmitters and acts at presynaptic sites to reduce transmitter release; such presynaptic P2X receptors occur at inhibitory and excitatory terminals in the medial nucleus of the trapezoid body (MNTB). We have investigated the mechanism of purinergic modulation during… CONTINUE READING

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