Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity.

@article{Ilie2006EndogenousAO,
  title={Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity.},
  author={Andrei Ilie and Dragos F. Ciocan and A Z{\`a}grean and Dragos Alexandru Nita and Leon Zagrean and Mihai Moldovan},
  journal={Journal of neurophysiology},
  year={2006},
  volume={96 5},
  pages={2809-14}
}
Cerebral ischemia induces a rapid suppression of spontaneous brain rhythms prior to major alterations in ionic homeostasis. It was found in vitro during ischemia that the rapidly formed adenosine, resulting from the intracellular breakdown of ATP, may inhibit synaptic transmission via the A(1) receptor subtype. The link between endogenous A(1) receptor activation during ischemia and the suppression of spontaneous electrocortical activity has not yet been established in the intact brain. The aim… CONTINUE READING

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