Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

@inproceedings{Blauwkamp2012EndogenousWS,
  title={Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors},
  author={Timothy A. Blauwkamp and Shelly Nigam and Reza Ardehali and Irving L Weissman and Roeland Nusse},
  booktitle={Nature communications},
  year={2012}
}
The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the cells are heterogeneous with respect to endogenous Wnt signalling activity. Moreover, the level of Wnt signalling activity in individual cells correlates with differences in clonogenic potential and lineage-specific differentiation propensity. The addition of Wnt protein or, conversely, a small-molecule Wnt inhibitor… CONTINUE READING
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Di#erential requirement for the dual functions of betacatenin in embryonic stem cell self-renewal and germ layer formation

  • N Lyashenko
  • Nat. Cell Biol
  • 2011

Embryonic stem cells require Wnt proteins to prevent di#erentiation to epiblast stem cells

  • D ten Berge
  • Nat. Cell Biol
  • 2011

Opposing e#ects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

  • F Yi
  • Nat. Cell. Biol
  • 2011

Comparison of de"ned culture systems for feeder cell free propagation of human embryonic stem cells

  • V Akopian
  • In Vitro Cell Dev. Biol. Anim
  • 2010

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