Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.

@article{Xiao2018EndogenousRO,
  title={Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.},
  author={Xiangwei Xiao and Ping Guo and C Takahiro Shiota and Ting Zhang and Gina M Coudriet and Shane Fischbach and Krishna L. Prasadan and Joseph Fusco and Sabarinathan Ramachandran and Piotr Witkowski and Jon D Piganelli and George K. Gittes},
  journal={Cell stem cell},
  year={2018},
  volume={22 1},
  pages={78-90.e4}
}
Successful strategies for treating type 1 diabetes need to restore the function of pancreatic beta cells that are destroyed by the immune system and overcome further destruction of insulin-producing cells. Here, we infused adeno-associated virus carrying Pdx1 and MafA expression cassettes through the pancreatic duct to reprogram alpha cells into functional beta cells and normalized blood glucose in both beta cell-toxin-induced diabetic mice and in autoimmune non-obese diabetic (NOD) mice. The… CONTINUE READING

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