Endogenous RNA Interference Provides a Somatic Defense against Drosophila Transposons

@article{Chung2008EndogenousRI,
  title={Endogenous RNA Interference Provides a Somatic Defense against Drosophila Transposons},
  author={Wei-Jen Chung and Katsutomo Okamura and Raquel Mart{\'i}n and Eric C. Lai},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={795-802}
}
BACKGROUND Because of the mutagenic consequences of mobile genetic elements, elaborate defenses have evolved to restrict their activity. A major system that controls the activity of transposable elements (TEs) in flies and vertebrates is mediated by Piwi-interacting RNAs (piRNAs), which are approximately 24-30 nucleotide RNAs that are bound by Piwi-class effectors. The piRNA system is thought to provide primarily a germline defense against TE activity. RESULTS Here, we describe a second… CONTINUE READING
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