Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

@article{Fu2006EndogenousRP,
  title={Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.},
  author={Ying Fu and Xinyan Huang and Huailing Zhong and Richard M. Mortensen and L G D'alecy and Richard R. Neubig},
  journal={Circulation research},
  year={2006},
  volume={98 5},
  pages={659-66}
}
Cardiac automaticity is controlled by G protein-coupled receptors, such as adrenergic, muscarinic, and adenosine receptors. The strength and duration of G protein signaling is attenuated by regulator of G protein signaling (RGS) proteins acting as GTPase-activating proteins for Galpha subunits; however, little is known about the role of endogenous RGS proteins in cardiac function. We created point mutations in Galpha subunits that disrupt Galpha-RGS binding and introduced them into embryonic… CONTINUE READING