Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor

@article{Christian2013EndogenousPA,
  title={Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor},
  author={Catherine A Christian and Anne G. Herbert and Rebecca L. Holt and Kathy K Peng and Kyla D. Sherwood and Susanne Pangratz-Fuehrer and Uwe Rudolph and John R. Huguenard},
  journal={Neuron},
  year={2013},
  volume={78},
  pages={1063-1074}
}
Benzodiazepines (BZs) allosterically modulate γ-aminobutyric acid type-A receptors (GABAARs) to increase inhibitory synaptic strength. Diazepam binding inhibitor (DBI) protein is a BZ site ligand expressed endogenously in the brain, but functional evidence for BZ-mimicking positive modulatory actions has been elusive. We demonstrate an endogenous potentiation of GABAergic synaptic transmission and responses to GABA uncaging in the thalamic reticular nucleus (nRT) that is absent in both nm1054… CONTINUE READING
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