Endogenous Plasma Peptide Detection and Identification in the Rat by a Combination of Fractionation Methods and Mass Spectrometry

Abstract

Mass spectrometry-based analyses are essential tools in the field of biomarker research. However, detection and characterization of plasma low abundance and/or low molecular weight peptides is challenged by the presence of highly abundant proteins, salts and lipids. Numerous strategies have already been tested to reduce the complexity of plasma samples. The… (More)

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@inproceedings{Bertile2007EndogenousPP, title={Endogenous Plasma Peptide Detection and Identification in the Rat by a Combination of Fractionation Methods and Mass Spectrometry}, author={Fabrice Bertile and Flavie Robert and V{\'e}ronique Delval-Dubois and Sarah Sanglier and Christine Schaeffer and Alain van Dorsselaer}, booktitle={Biomarker insights}, year={2007} }