Endogenous Pain Modulation Chapter 13 Descending Inhibitory Systems

@inproceedings{Pertovaara2005EndogenousPM,
  title={Endogenous Pain Modulation Chapter 13 Descending Inhibitory Systems},
  author={Antti Pertovaara and Armando J Almeida},
  year={2005}
}
It is well established that the brainstem has a significant role in regulating pain-related signals at the spinal cord level (for comprehensive reviews see Willis and Coggeshall, 1991; Sandkühler, 1996; Fields and Basbaum, 1999; Millan, 2002). It has been commonly considered that brainstem–spinal pathways predominantly inhibit pain. However, there is accumulating evidence indicating that descending pathways also have pain facilitatory effects (Urban and Gebhart, 1999; Pertovaara, 2000; Lima and… CONTINUE READING

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