Endogenous Orphanin FQ/Nociceptin Is Involved in the Development of Morphine Tolerance

@article{Chung2006EndogenousOF,
  title={Endogenous Orphanin FQ/Nociceptin Is Involved in the Development of Morphine Tolerance},
  author={Shinjae Chung and S Pohl and Joanne Zeng and Olivier Civelli and Rainer K Reinscheid},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={318},
  pages={262 - 267}
}
The neuropeptide orphanin FQ/nociceptin (OFQ/N) has been shown to counteract several effects of endogenous and exogenous opioids, and it has been proposed as an opioid-modulating agent involved in the development of morphine tolerance and dependence. However, conflicting results have been obtained from animal models using different protocols to induce morphine tolerance. Here, we report that both genetic and pharmacological blockade of OFQ/N signaling can effectively prevent development of… 

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