Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration

  title={Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration},
  author={A. Colasanti and G. Searle and C. Long and Samuel P. Hill and E. Rabiner},
  journal={Biological Psychiatry},
  • A. Colasanti, G. Searle, +2 authors E. Rabiner
  • Published 2012
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" dose, .5 mg/kg, or a sub-pharmacological "ultra-low" dose, 1.25 mg total dose or approximately .017 mg… CONTINUE READING
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