• DOI:10.1016/j.biopsych.2012.01.027
Corpus ID: 18555036

Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration

@article{Colasanti2012EndogenousOR,
  title={Endogenous Opioid Release in the Human Brain Reward System Induced by Acute Amphetamine Administration},
  author={A. Colasanti and G. Searle and C. Long and Samuel P. Hill and E. Rabiner},
  journal={Biological Psychiatry},
  year={2012},
  volume={72},
  pages={371-377}
}

A. Colasanti, G. Searle, +2 authors E. Rabiner

Published 2012

Psychology, Medicine

Biological Psychiatry

BACKGROUND We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" dose, .5 mg/kg, or a sub-pharmacological "ultra-low" dose, 1.25 mg total dose or approximately .017 mg… CONTINUE READING

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