Endogenous Neurotrophins and Trk Signaling in Diffuse Large B Cell Lymphoma Cell Lines Are Involved in Sensitivity to Rituximab-Induced Apoptosis

@inproceedings{Bellanger2011EndogenousNA,
  title={Endogenous Neurotrophins and Trk Signaling in Diffuse Large B Cell Lymphoma Cell Lines Are Involved in Sensitivity to Rituximab-Induced Apoptosis},
  author={Cynthia Bellanger and Lydie Dubanet and Michelle Lise and Anne-Laure M Fauchais and Dominique Bordessoule and Marie-Odile Jauberteau and Danielle Troutaud},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Diffuse large B-cell lymphoma (DLBCL) is a common and often fatal malignancy. Immunochemotherapy, a combination of rituximab to standard chemotherapy, has resulted in improved survival. However a substantial proportion of patients still fail to reach sustained remission. We have previously demonstrated that autocrine brain-derived neurotrophic factor (BDNF) production plays a function in human B cell survival, at least partly via sortilin expression. As neurotrophin receptor (Trks… CONTINUE READING

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