Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus.

@article{Bergeron2007EndogenousNR,
  title={Endogenous N-acetylaspartylglutamate reduced NMDA receptor-dependent current neurotransmission in the CA1 area of the hippocampus.},
  author={Richard Bergeron and Yukio Imamura and John V. Frangioni and Robert W Greene and Joseph T Coyle},
  journal={Journal of neurochemistry},
  year={2007},
  volume={100 2},
  pages={346-57}
}
N-Acetylaspartylglutamate (NAAG) is a neuropeptide found in high concentrations in the brain. Using whole-cell recordings of CA1 pyramidal neurons in acute hippocampal slices, we found that either (i) the application of exogenous NAAG or (ii) an increase of endogenous extracellular NAAG, caused by the inhibition of its catabolic enzyme glutamate carboxypeptidase II (GCP II), resulted in a significant reduction in the amplitude of the isolated NMDA receptor (NMDAR) component of the evoked… CONTINUE READING

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