Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells.

@article{Chua2011EndogenousMP,
  title={Endogenous MHC-related protein 1 is transiently expressed on the plasma membrane in a conformation that activates mucosal-associated invariant T cells.},
  author={Wei-Jen Chua and Sojung C. Kim and Nancy Myers and Shouxiong Huang and Lawrence Yu and Daved H. Fremont and Michael S Diamond and Ted H. Hansen},
  journal={Journal of immunology},
  year={2011},
  volume={186 8},
  pages={4744-50}
}
The development of mucosal-associated invariant T (MAIT) cells is dependent upon the class Ib molecule MHC-related protein 1 (MR1), commensal bacteria, and a thymus. Furthermore, recent studies have implicated MR1 presentation to MAIT cells in bacteria recognition, although the mechanism remains undefined. Surprisingly, however, surface expression of MR1 has been difficult to detect serologically, despite ubiquitous detection of MR1 transcripts and intracellular protein. In this article, we… CONTINUE READING