Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA.

@article{Zoelen2011EndogenousMP,
  title={Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA.},
  author={Marieke A. D. van Zoelen and Marleen I. Verstege and Christian Draing and Regina de Beer and Cornelis van’t Veer and Sandrine Florquin and Paul Bresser and Jaring S van der Zee and Anje A. te Velde and Sonja von Aulock and Tom van der Poll},
  journal={Molecular immunology},
  year={2011},
  volume={48 12-13},
  pages={
          1468-76
        }
}
Monocyte chemoattractant protein 1 (MCP-1) plays an important role in leukocyte recruitment to sites of infection and inflammation. In addition, MCP-1 may attenuate inflammation by virtue of its capacity to inhibit the production of proinflammatory cytokines. We here investigated the role of MCP-1 in lung inflammation induced by lipopolysaccharide (LPS) or lipoteichoic acid (LTA), constituents of the gram-negative and gram-positive bacterial cell wall, respectively. Healthy humans demonstrated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

  • M. C. Dessing, A. F. de Vos, S. Florquin, T. van der Poll
  • Infect. Immun
  • 2006
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Pathogen Recognition and Innate Immunity

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Novel chemokine responsiveness and mobilization of neutrophils during sepsis.

VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

MCP-1 protects mice in lethal endotoxemia.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Regulatory effects of iNOS on acute lung inflammatory responses in mice.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL