Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain.

@article{Pichery2012EndogenousII,
  title={Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain.},
  author={M{\'e}lanie Pichery and Emilie Mirey and Pascale Mercier and Emma Lefrançais and Arnaud Dujardin and Nathalie Ortega and Jean-Philippe Girard},
  journal={Journal of immunology},
  year={2012},
  volume={188 7},
  pages={3488-95}
}
IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that signals through the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, invariant NKT and NK cells, Th2 lymphocytes, and type 2 innate immune cells (natural helper cells, nuocytes, and innate helper 2 cells). Little is known about endogenous IL-33; for instance, the cellular sources of IL-33 in mouse tissues have not yet been defined. In this study, we generated an Il-33… CONTINUE READING

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