Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.

  title={Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.},
  author={Chun Geun Lee and Dominik Hartl and Hiroshi Matsuura and Felicity M Dunlop and Pierre D Scotney and Louis Jerry Fabri and Andrew D. Nash and Ning-yuan Chen and Chu-Yan Tang and Qingsheng Chen and Robert J Homer and Manuel Baca and Jack A Elias},
  journal={American journal of respiratory cell and molecular biology},
  volume={39 6},
IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully defined. We hypothesized that IL-11, signaling via IL-11Ralpha, plays an important role in aeroallergen-induced Th2 inflammation and mucus metaplasia. To test this hypothesis, we compared the responses induced by the aeroallergen ovalbumin (OVA) in wild-type (WT) and IL-11Ralpha-null mutant mice. We also generated and defined the effects… CONTINUE READING


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