Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

  title={Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits},
  author={Christopher Hine and Eylul Harputlugil and Yue Zhang and Christoph Ruckenstuhl and Byung Cheon Lee and Lear E Brace and Alban Longchamp and Jose Humberto Trevi{\~n}o-Villarreal and P. A. Lome{\'i} Mejia and C. Keith Ozaki and Rui Wang and Vadim N. Gladyshev and Frank Madeo and William B. Mair and James R. Mitchell},
Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying nutritional and molecular mechanisms remain elusive. In a mouse model of DR-mediated stress resistance, we found that sulfur amino acid (SAA) restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine γ-lyase (CGL), resulting in increased hydrogen sulfide (H2S) production and protection from hepatic… CONTINUE READING
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