Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

  title={Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits},
  author={Christopher Hine and Eylul Harputlugil and Yue Zhang and Christoph Ruckenstuhl and Byung Cheon Lee and Lear E Brace and Alban Longchamp and Jose Humberto Trevi{\~n}o-Villarreal and P. A. Lome{\'i} Mejia and C. Keith Ozaki and Rui Wang and Vadim N. Gladyshev and Frank Madeo and William B. Mair and James R. Mitchell},
Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying nutritional and molecular mechanisms remain elusive. In a mouse model of DR-mediated stress resistance, we found that sulfur amino acid (SAA) restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine γ-lyase (CGL), resulting in increased hydrogen sulfide (H2S) production and protection from hepatic… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 73 times over the past 90 days. VIEW TWEETS
Blog posts, news articles and tweet counts and IDs sourced by