Endogenous HMGB1 regulates autophagy

@inproceedings{Tang2010EndogenousHR,
  title={Endogenous HMGB1 regulates autophagy},
  author={Daolin Tang and Rui Kang and Kristen M. Livesey and Chun-Wei Cheh and Adam M. Farkas and Patricia Loughran and George Hoppe and Marco Emilio Bianchi and Kevin J Tracey and Herbert J. Zeh and Michael T Lotze},
  booktitle={The Journal of cell biology},
  year={2010}
}
Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. Stimuli that enhance reactive oxygen species promote cytosolic translocation of HMGB1 and thereby enhance… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 35 references

How to interpret LC3 immunoblotting.

View 3 Excerpts
Highly Influenced

ROS, mitochondria and the regulation of autophagy.

Trends in cell biology • 2007
View 7 Excerpts
Highly Influenced

Autophagy in the Pathogenesis of Disease

View 5 Excerpts
Highly Influenced

High-mobility group box 1 and cancer.

Biochimica et biophysica acta • 2010
View 3 Excerpts

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