Endogenous HMGB1 regulates autophagy

  title={Endogenous HMGB1 regulates autophagy},
  author={Daolin Tang and Rui Kang and Kristen M. Livesey and Chun-Wei Cheh and Adam M. Farkas and Patricia Loughran and George Hoppe and Marco Emilio Bianchi and Kevin J Tracey and Herbert J. Zeh and Michael T Lotze},
  booktitle={The Journal of cell biology},
Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. Stimuli that enhance reactive oxygen species promote cytosolic translocation of HMGB1 and thereby enhance… CONTINUE READING
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