Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein.

@article{Weaver2013EndogenousGR,
  title={Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein.},
  author={Carole Weaver and Christina Paulette Leidel and Lukasz Szpankowski and Nicole M Farley and George T. Shubeita and Lawrence S. B. Goldstein},
  journal={Traffic},
  year={2013},
  volume={14 3},
  pages={
          295-308
        }
}
Neurons rely on microtubule (MT) motor proteins such as kinesin-1 and dynein to transport essential cargos between the cell body and axon terminus. Defective axonal transport causes abnormal axonal cargo accumulations and is connected to neurodegenerative diseases, including Alzheimer's disease (AD). Glycogen synthase kinase 3 (GSK-3) has been proposed to be a central player in AD and to regulate axonal transport by the MT motor protein kinesin-1. Using genetic, biochemical and biophysical… CONTINUE READING
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