Endogenous GLP-1 modulates hippocampal activity in beta-amyloid protein-treated rats.

@article{Oka1999EndogenousGM,
  title={Endogenous GLP-1 modulates hippocampal activity in beta-amyloid protein-treated rats.},
  author={Junichiro Oka and Etsuko Suzuki and Norihisa Goto and Tsutomu Kameyama},
  journal={Neuroreport},
  year={1999},
  volume={10 14},
  pages={2961-4}
}
We examined the relationship between the histochemical distribution of endogenous GLP-1 (7-36) amide in the hippocampus and memory impairment assessed by a step-through type passive avoidance task in rats continuously infused with beta-amyloid protein (1-40) into the lateral cerebroventricle using a mini-osmotic pump. Our results demonstrated that endogenous GLP-1 (7-36) amide appears in the hippocampus accompanied by progression of memory impairment. Electrophysiological studies also indicated… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…