Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells.

Abstract

Clustered DNA damages-multiple oxidized bases, abasic sites, or strand breaks within a few helical turns-are potentially mutagenic and lethal alterations induced by ionizing radiation. Endogenous clusters are found at low frequencies in unirradiated normal human cells and tissues. Radiation-sensitive hematopoietic cells with low glycosylase levels (TK6 and… (More)
DOI: 10.1016/j.freeradbiomed.2008.08.007

Topics

6 Figures and Tables

Cite this paper

@article{Bennett2008EndogenousDD, title={Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells.}, author={Paula V. Bennett and Alexander A. Ishchenko and J. Laval and Brigitte Paap and Betsy M. Sutherland}, journal={Free radical biology & medicine}, year={2008}, volume={45 9}, pages={1352-9} }