Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.

@article{Land2013EndogenousAD,
  title={Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.},
  author={Allison M. Land and Emily K. Law and Michael A Carpenter and Lela Lackey and William L. Brown and Reuben S Harris},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 24},
  pages={17253-60}
}
APOBEC3A (A3A) is a myeloid lineage-specific DNA cytosine deaminase with a role in innate immunity to foreign DNA. Previous studies have shown that heterologously expressed A3A is genotoxic, suggesting that monocytes may have a mechanism to regulate this enzyme. Indeed, we observed no significant cytotoxicity when interferon was used to induce the… CONTINUE READING