Endogenous ACTH, not only alpha-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms.

@article{Schulz2010EndogenousAN,
  title={Endogenous ACTH, not only alpha-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms.},
  author={Carla Schulz and Kerstin Paulus and Ralf Lobmann and Mary F. Dallman and Hendrik Lehnert},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 2},
  pages={E237-44}
}
ACTH and alpha-melanocyte-stimulating hormone (alpha-MSH) are both consecutively processed from proopiomelanocortin (POMC), which is synthesized in hypothalamic arcuate neurons innervating the paraventricular nuclei (PVN). POMC secretion/synthesis is regulated by energy availability. ACTH and alpha-MSH bind with equal affinity to melanocortin-4 receptors and elicit similar effects on signal transduction in-vitro. Endogenous alpha-MSH thus far is believed to be the major physiological agonist… CONTINUE READING

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