Endogenization and excision of human herpesvirus 6 in human genomes

@article{Liu2020EndogenizationAE,
  title={Endogenization and excision of human herpesvirus 6 in human genomes},
  author={Xiaoxi Liu and Shunichi Kosugi and Rie Koide and Yoshiki Kawamura and Jumpei Ito and Hiroki Miura and Nana Matoba and Motomichi Matsuzaki and Masashi Fujita and Anselmo Jiro Kamada and Hidewaki Nakagawa and Gen Tamiya and Koichi Matsuda and Yoshinori Murakami and Michiaki Kubo and Amr Aswad and Kei Sato and Yukihide Momozawa and Jun Ohashi and Chikashi Terao and Tetsushi Yoshikawa and Nicholas F. Parrish and Yoichiro Kamatani},
  journal={PLoS Genetics},
  year={2020},
  volume={16}
}
Sequences homologous to human herpesvirus 6 (HHV-6) are integrated within the nuclear genome of about 1% of humans, but it is not clear how this came about. It is also uncertain whether integrated HHV-6 can reactivate into an infectious virus. HHV-6 integrates into telomeres, and this has recently been associated with polymorphisms affecting MOV10L1. MOV10L1 is located on the subtelomere of chromosome 22q (chr22q) and is required to make PIWI-interacting RNAs (piRNAs). As piRNAs block germline… Expand
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