Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis.

@article{Yu2009EndodomainDI,
  title={Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis.},
  author={Hung-Hsiang Yu and Jacob Shun-Jen Yang and Jian Wang and Yaling Huang and Tzumin Lee},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 6},
  pages={1904-14}
}
Drosophila Down syndrome cell adhesion molecule (Dscam) can be variably spliced to encode 152,064 distinct single-pass transmembrane proteins. In addition to 19,008 possible ectodomains and two alternative transmembrane segments, it may carry endodomains containing or lacking exons 19 and 23. Here, we determine the role of Dscam endodomain diversity in neural development. Dscam with full-length endodomain is largely restricted to embryogenesis. In contrast, most Dscams lack exons 19 and 23 at… CONTINUE READING

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