Endoderm and heart development.

  title={Endoderm and heart development.},
  author={John W. Lough and Yukiko Sugi},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={217 4},
Since the first half of the 20th century, experimental embryologists have noted a relationship between endoderm cells and the development of cardiac tissue from mesoderm. During the past decade, the accumulation of evidence for an obligatory interaction between endoderm and mesoderm during the specification and terminal differentiation of myocardial, and more recently endocardial, cells has markedly accelerated. Moreover, the endoderm-derived molecules that may regulate these processes are… CONTINUE READING