Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.

@article{Eliasson1996EndocytosisOS,
  title={Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.},
  author={Lena Eliasson and Peter Proks and Carina E Amm{\"a}l{\"a} and Frances M. Ashcroft and Krister Bokvist and Erik Renstr{\"o}m and Patrik Rorsman and Paul A. Smith},
  journal={The Journal of physiology},
  year={1996},
  volume={493 ( Pt 3)},
  pages={755-67}
}
1. To investigate the mechanisms regulating the reuptake of secretory granule membranes following regulated exocytosis, we have monitored changes in cell capacitance in single pancreatic beta-cells. 2. Membrane retrieval (endocytosis) occurred both in a continuous manner and in abrupt steps, corresponding to the simultaneous retrieval of 50-100 granules. The large endocytotic steps were associated with a conductance change of about 1 nS which we attribute to the formation of a fission pore with… CONTINUE READING

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