Corpus ID: 8355480

Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors.

@article{LaurentMatha1998EndocytosisOP,
  title={Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors.},
  author={Val{\'e}rie Laurent-Matha and M. R. Farnoud and A Lucas and Christian Rougeot and Maur{\'i}cio S. Garcia and Henri Rochefort},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 17)},
  pages={
          2539-49
        }
}
  • Valérie Laurent-Matha, M. R. Farnoud, +3 authors Henri Rochefort
  • Published in Journal of cell science 1998
  • Biology, Medicine
  • Cathepsin D trafficking is altered in cancer cells, leading to increased secretion of the pro-enzyme, which can be reinternalized by the same cancer cells and by stromal cells. We studied pro-cathepsin D endocytosis in two human breast cancer cell lines (MDA-MB231, MCF-7) and in human normal fibroblasts. Pro-enzyme uptake was studied indirectly through immunofluorescence analysis of anti-pro-cathepsin D monoclonal antibodies internalized in living cells. Both cancer cell lines internalized the… CONTINUE READING

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