Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

@article{Schwartz1996EndocytosisOM,
  title={Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein},
  author={Olivier Schwartz and Val{\'e}rie Mar{\'e}chal and Sylvie Le Gall and François A. Lemonnier and J F Heard},
  journal={Nature Medicine},
  year={1996},
  volume={2},
  pages={338-342}
}
Like other pathogenic viruses, HIV–1 down–modulates surface expression of major histocompatibility complex class I (MHC–I) molecules in infected cells, thus impairing lysis by cytotoxic T lymphocytes1,2. We have observed that this phenomenon depends on the expression of Nef. nef is an early gene of primate lentiviruses3, which is necessary for maintaining high virus loads and inducing AIDS (ref. 4). Nef is not necessary for viral replication in vitro and stimulates the endocytosis of CD4 (ref… CONTINUE READING
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