Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.

@article{Cnop2000EndocytosisOL,
  title={Endocytosis of low-density lipoprotein by human pancreatic beta cells and uptake in lipid-storing vesicles, which increase with age.},
  author={Miriam Cnop and Annick Y Grupping and Anne Hoorens and Luc Bouwens and Miriam A. Pipeleers-Marichal and Dani{\"e}l G. Pipeleers},
  journal={The American journal of pathology},
  year={2000},
  volume={156 1},
  pages={237-44}
}
Studies with I(125)-labeled low-density lipoproteins (LDLs) have shown the presence of high-affinity LDL receptors on insulin-producing beta cells but not on neighboring alpha cells. By using gold-labeled lipoproteins, we demonstrate receptor-mediated endocytosis of LDLs and very low-density lipoproteins in rat and human beta cells. Specific for human beta cells is the fusion of LDL-containing endocytotic vesicles with lipid-storing vesicles (LSVs; diameter, 0.6-3.6 microm), which are absent in… CONTINUE READING

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