Endocytosis of human immunodeficiency virus 1 (HIV-1) in astrocytes: a fiery path to its destination.

@article{Chauhan2015EndocytosisOH,
  title={Endocytosis of human immunodeficiency virus 1 (HIV-1) in astrocytes: a fiery path to its destination.},
  author={Ashok Chauhan and Mehrab Khandkar},
  journal={Microbial pathogenesis},
  year={2015},
  volume={78},
  pages={1-6}
}
Despite successful suppression of peripheral HIV-1 infection by combination antiretroviral therapy, immune activation by residual virus in the brain leads to HIV-associated neurocognitive disorders (HAND). In the brain, several types of cells, including microglia, perivascular macrophage, and astrocytes have been reported to be infected by HIV-1. Astrocytes, the most abundant cells in the brain, maintain homeostasis. The general consensus on HIV-1 infection in astrocytes is that it produces… CONTINUE READING

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