Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.

  title={Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.},
  author={Kirsi Riento and Manfred Frick and Ingmar Schafer and Benjamin J Nichols},
  journal={Journal of cell science},
  volume={122 Pt 7},
Flotillin-1 and flotillin-2 co-assemble into plasma membrane microdomains that are involved in the endocytosis of molecules such as glycosyl phosphatidylinositol (GPI)-linked proteins. Previous studies suggest that budding of flotillin microdomains from the plasma membrane is a tightly regulated process. Here, we demonstrate that endocytosis of flotillins is regulated by the Src family kinase Fyn. The Src kinase inhibitor PP2 prevents EGF-induced flotillin internalisation, and EGF-induced… CONTINUE READING
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