Endocytosis of PEGylated agents enhances cancer imaging and anticancer efficacy.

  title={Endocytosis of PEGylated agents enhances cancer imaging and anticancer efficacy.},
  author={Kuo-Hsiang Chuang and Hsin-Ell Wang and Fang-ming Chen and Shey-Cherng Tzou and Chiu-Min Cheng and Ya-Chen Chang and Wei-Lung Tseng and Jentaie Shiea and S Lin and Jaw-Yuan Wang and B M Chen and Steve R Roffler and Tian-Lu Cheng},
  journal={Molecular cancer therapeutics},
  volume={9 6},
PEGylated nanoparticles and macromolecules are increasingly used in cancer imaging and anticancer treatment. The role of receptor-mediated endocytosis in the efficacy of these agents, however, has not been clearly defined. Here, we developed a matched pair of endocytic and nonendocytic receptors to directly and unambiguously assess this issue. The ligand-binding domains of the low-density lipoprotein receptor (LDLR) or a truncated LDLR lacking the NPXY endocytosis motif (DeltaLDLR) were… CONTINUE READING