Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.

Abstract

The sphingosine 1-phosphate receptor 1 (S1PR1) is one of five G protein-coupled receptors activated by the lipid sphingosine 1-phosphate (S1P). Stimulation of S1PR1 by binding S1P or the synthetic agonist FTY720P results in rapid desensitization, associated in part with depletion of receptor from the cell surface. We report here combining spinning disc… (More)
DOI: 10.1111/tra.12343

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@article{Reeves2016EndocytosisOL, title={Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.}, author={Patrick M. Reeves and Y Kang and Tom Kirchhausen}, journal={Traffic}, year={2016}, volume={17 1}, pages={40-52} }