Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes.

@article{Chauhan2014EndocytosismediatedHE,
  title={Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes.},
  author={Ashok Chauhan and Rajeev Mehla and Theophilus Sunder Vijayakumar and Indhira Handy},
  journal={Virology},
  year={2014},
  volume={456-457},
  pages={1-19}
}
Astrocytes protect neurons but also evoke a proinflammatory response to injury and viral infections including HIV. We investigated the mechanism of HIV-1 infection in primary astrocytes, which showed minimal but productive viral infection independent of CXCR4. As with ectopic-CD4-expressing astrocytes, lysosomotropic agents led to increased HIV-1 infection in wild-type but not Rabs 5, 7, and 11-ablated astrocytes. Instead, HIV-1 infection was decreased in Rab-depleted astrocytes, corroborating… CONTINUE READING
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