Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1

  title={Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1},
  author={Kirsten Sandvig and Sjur Olsnes and James E. C. Brown and Ole William Petersen and Bo van Deurs},
  journal={The Journal of Cell Biology},
  pages={1331 - 1343}
Evidence is presented that endocytosis is involved in the transport to the cytosol of the cytotoxin from Shigella dysenteriae 1, Shiga toxin, which acts by removal of a single adenine residue in 28-S ribosomal RNA. Inhibition of endocytosis by ATP depletion of the cells prevented toxin uptake. Exposure of HeLa S3 and Vero cells to toxin at low extracellular pH, where translocation to the cytosol, but not endocytosis is inhibited, allowed the toxin to accumulate in a compartment where it was… CONTINUE READING
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