Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.

@article{Opresko1995EndocytosisAL,
  title={Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.},
  author={Lee K. Opresko and C P Chang and B H Will and Patrick M. Burke and Gordon N. Gill and H. Steven Wiley},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 9},
  pages={4325-33}
}
Ligand-induced internalization of the epidermal growth factor receptor (EGFR) leads to accelerated receptor degradation. Two models have been proposed to explain this. In the first model, induced internalization expands the intracellular pool of receptors, leading to enhanced lysosomal targeting. The second model proposes that activation of intrinsic receptor kinase activity induces inward vesiculation of endosomes, thus interrupting receptor recycling. To test these models, we created EGFR… CONTINUE READING

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