Endocytosis and intracellular dissociation rates of human insulin-insulin receptor complexes by quantum dots in living cells.


Insulin signaling is involved in glucose metabolism, cellular growth, and differentiation. Its function is altered in diabetes and many cancer types. Insulin binding to insulin receptor (IR) triggers diverse signaling pathways. However, signal transduction by IR is not mediated exclusively at the cell surface. Activated ligand-receptor complexes are… (More)
DOI: 10.1021/bc300526d