Endocytosis and degradation of murine anti-human CD3 monoclonal antibodies by normal and malignant T-lymphocytes.

@article{Press1988EndocytosisAD,
  title={Endocytosis and degradation of murine anti-human CD3 monoclonal antibodies by normal and malignant T-lymphocytes.},
  author={Oliver W Press and John A Hansen and Andrew G. Farr and Perrine J. Martin},
  journal={Cancer research},
  year={1988},
  volume={48 8},
  pages={
          2249-57
        }
}
Treatment of lymphoid malignancies with monoclonal antibodies (mAbs) and immunoconjugates is a promising new immunotherapeutic approach. However, few published studies have examined in detail the subcellular fate of antibodies following binding to lymphocyte cell surface antigens. In this study, we have investigated the disposition of monoclonal anti-CD3 antibody 64.1 following binding to normal and malignant T-lymphocytes by using cellular radioimmunoassays and immunoperoxidase and immunogold… CONTINUE READING

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